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硫化氢在炎症和自噬等病理中作用与机制的研究进展

周骊,  林昌俊,  周鹏

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文章导航 > 热带生物学报  > 2019 >  10(2): 208-214
周骊, 林昌俊, 周鹏. 硫化氢在炎症和自噬等病理中作用与机制的研究进展[J]. 热带生物学报, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
引用本文: 周骊, 林昌俊, 周鹏. 硫化氢在炎症和自噬等病理中作用与机制的研究进展[J]. 热带生物学报, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
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ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
Citation: ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
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硫化氢在炎症和自噬等病理中作用与机制的研究进展

doi: 10.15886/j.cnki.rdswxb.2019.02.018

  • 1. 兰州大学 生命科学学院 生物物理研究所, 兰州 730000;

  • 2. 中国热带农业科学院 热带生物技术研究所, 海口 571101

详细信息
    第一作者:

    周骊(1994-),男,兰州大学生命科学学院2017年级硕士研究生,E-mail:595929113@qq.com

    通信作者:

    林昌俊(1976-),男,副教授,硕士生导师.研究方向:细胞生物学与细胞生物物理学,E-mail:linc@lzu.edu.cn

    周鹏(1963-),男,研究员,博士生导师.研究方向:分子生物学及抗病基因工程,E-mail:zhp6301@126.com

  • 中图分类号: R36

Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy

  • 1. Institute of Biophysics School of Life Sciences, Lanzhou University, Lanzhou Gansu, 730000 China;

  • 2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou, Hainan 571101 China

  • 摘要: 硫化氢（H2S）是一种内源性气体信号分子,常常与一氧化碳和一氧化氮协同作用,在血管生成、神经活动、葡萄糖代谢、抗氧化和炎症反应等调节功能中发挥着重要作用。由于内源H2S代谢异常与许多疾病如癌症、高血压、糖尿病和神经退行性疾病等有关,因此,调控内源H2S的量对于治疗H2S相关的疾病以及临床上的研究具有重要意义。笔者重点综述了近年来H2S供体来源和H2S在炎症、自噬等相关病理方面的研究进展,以及内源H2S量精确化潜在的研究方式,同时对H2S研究前景和发展方向作了展望。
    Abstract: Hydrogen sulfide（H2S） is an endogenous gas signaling molecule, often synergistic with carbon monoxide and nitric oxide, and plays an important role in the regulation of angiogenesis, neural activity, glucose metabolism, antioxidant and inflammatory reactions. However, endogenous H2S metabolic abnormalities are associated with many diseases, including cancer, hypertension, diabetes, and neurodegenerative diseases. Therefore, the regulation of endogenous H2S is of great significance for the treatment of the H2S related diseases and clinical studies. In the present study, the main research method is to evaluate the effect of endogenous H2S in human pathology, supplemented with exogenous H2S so as to seek breakthroughs in pathology and find therapeutic targets of H2S and its products in diseases by relying on this research method. In this paper, we will focus on the recent progress of H2S donor and H2S in inflammation and autophagy, two of the most popular pathology-related studies, and the potential research methods of endogenous H2S quantifying.The research prospect and development direction of H2S are prospected.
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    [31] XIE L, YU SF, YANG K, et al.Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury[J/OL].Oxidative Medicine and Cellular Longevity, 2017.https://doi.org/10.1155/2017/8640284.
    [32] ZHANG M Y, SHAN H Y, CHANG P, et al.Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice[J].Plos One, 2014, 9 (1):87241.
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    • 收稿日期:  2019-05-08
    • 修回日期:  2019-05-30

    硫化氢在炎症和自噬等病理中作用与机制的研究进展

    doi: 10.15886/j.cnki.rdswxb.2019.02.018
    • 1. 兰州大学 生命科学学院 生物物理研究所, 兰州 730000;
    • 2. 中国热带农业科学院 热带生物技术研究所, 海口 571101
      • 作者简介:

      周骊(1994-),男,兰州大学生命科学学院2017年级硕士研究生,E-mail:595929113@qq.com

      通讯作者: 林昌俊(1976-),男,副教授,硕士生导师.研究方向:细胞生物学与细胞生物物理学,E-mail:linc@lzu.edu.cn; 周鹏(1963-),男,研究员,博士生导师.研究方向:分子生物学及抗病基因工程,E-mail:zhp6301@126.com
    • 收稿日期: 2019-05-08
    • 修回日期: 2019-05-30

    • 中图分类号: R36

    摘要: 硫化氢（H2S）是一种内源性气体信号分子,常常与一氧化碳和一氧化氮协同作用,在血管生成、神经活动、葡萄糖代谢、抗氧化和炎症反应等调节功能中发挥着重要作用。由于内源H2S代谢异常与许多疾病如癌症、高血压、糖尿病和神经退行性疾病等有关,因此,调控内源H2S的量对于治疗H2S相关的疾病以及临床上的研究具有重要意义。笔者重点综述了近年来H2S供体来源和H2S在炎症、自噬等相关病理方面的研究进展,以及内源H2S量精确化潜在的研究方式,同时对H2S研究前景和发展方向作了展望。

    English Abstract

    周骊, 林昌俊, 周鹏. 硫化氢在炎症和自噬等病理中作用与机制的研究进展[J]. 热带生物学报, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
    引用本文: 周骊, 林昌俊, 周鹏. 硫化氢在炎症和自噬等病理中作用与机制的研究进展[J]. 热带生物学报, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
    shu
    ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
    Citation: ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
    shu

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