Keywords: 
• QuEChERS /
• high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） /
• residues of veterinary drugs /
• marine products

Abstract: The optimized QuEChERS sample preparation method and high performance liquid chromatography mass spectrometry method were used to establish a rapid,efficient,high-sensitivity detection method for early screening of multi-residues of veterinary drugs and banned compounds of 21 drugs in four groups,such as the sulfanilamides,quinolones,tetracyclinesand Leucomalachite greenin oysters,scallops,squid,and cuttlefish.The 21 compounds had a good linear relationship in the corresponding range,the correlation coefficient r was greater than 0. 9995,the recovery was in the range of 65. 26% to 113. 5%,the relative standard deviation was less than 6. 78%,and the method had good repeatability. The detection precision within and between days was less than 6. 26% and 6. 02%,respectively. The limit of detection was less than 0. 8 μg·kg^-1,and the limit of quantitation was less than 2. 5 μg·kg^-1. This method was applied to detect the residues of 21 compounds in four soft shellfish marine products including 150 accessions of oysters,scallops,squid and cuttlefish in 8 regions of Guangdong Province,such as Shenzhen,Dongguan,Zhaoqing,Shantou,Maoming,Jiangmen,Shanwei and Huizhou in Guangdong Province,and no residuces was detected therein. In summary,this detection method is good in reproducibility,high in sensitivity,and reliable in detection results,and provides referencce for detection of the residuces of the 21 compounds such as sulfonamides,quinolones,tetracyclines,and malachite green in the 4 groups in oysters,scallops,squid,and cuttlefish.