摘要:
采用ODS、硅胶、Sephadex LH-20等柱色谱技术从瑞香科(Thymelaeaceae)拟沉香属(Gyrinops)植物柳叶拟沉香(Gyrinops salicifolia Ridl)分离得到9个2-(2-苯乙基)色酮类化合物,运用波谱学方法鉴定其结构,并采用Elman比色法对全部化合物进行活性测试。结果表明,柳叶拟沉香中分离的化合物结构分别为:6-羟基-2-(2-苯乙基)色酮(化合物1)、6-羟基-2-[2-(4-甲氧基苯)乙基]色酮(化合物2)、6,8-二羟基-2-[2-(4-甲氧基苯)乙基]色酮(化合物3)、6-甲氧基-2-[2-(3-甲氧基-4-羟基苯)乙基]色酮(化合物4)、6-羟基-7-甲氧基-2-[2-(4-甲氧基苯)乙基]色酮(化合物5)、(5R,6R,7S,8R)-5,6,7,8-四氢-5,6,7,8-四羟基-2-(2-苯乙基)-4氢-色酮(化合物6)、5α,6β,7β-三羟基-8α-甲氧基-2-(2-苯乙基)-4氢-色酮(化合物7)、(5S,6S,7S,8R)-2-[2-(4-甲氧基苯)乙基]-5,6,7,8-四羟基-5,6,7,8-4氢-色酮(化合物8)和8-氯-6-羟基-2-(2-苯乙基)色酮(化合物9)。从拟沉香属植物所产沉香中分离得到以上化合物均未见报道。化合物2,4,8,9对乙酰胆碱酯酶具有一定的抑制活性。
Abstract:
Nine derivatives of 2-（ 2-phenylethyl） chromone were isolated from the agarwood originating from Gyrinops salicifolia by the column chromatography method with ODS,silica gel,Sephadex LH-20,etc,and their structures were then identified by using wave spectroscopy. The compounds were identified by using colorimetry as 6-hydroxy-2-（ 2-phenylethyl） chromone（ 1）,6-hydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 2）,6,8-dihydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 3）,6-methoxy-2-[2-（ 3-methoxy-4-hydroxyphenyl） ethyl] chromone（ 4）,（ 5R,6R,7S,8R）-5,6,7,8-tetrahydro-5,6,7,8-hydroxy-2-（ 2-phenylethyl）-4-hydrogen-chromone（ 5）,5α,6β,7β,8α-trihydroxy-methoxy-2-（ 2-phenylethyl）-4 hydrogen-chromone（ 6）,6-hydroxy-7-methoxy2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 7）,（ 5S,6S,7S,8R）-2-[2-（ 4-methoxyphenyl） ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone（ 8） and 8-chloro-6-hydroxy-2-（ 2-phenylethyl）chromen-4-one（ 9）. All of the compounds were isolated from agarwood originating from Gyrinops salicifolia for the first time. All the chemical constituents above were tested for acetylcholinesterase inhibitory activity using the Ellman method. The result indicated that compounds 2,4,8,9 exhibited inhibitory activities against acetylcholinesterase.
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