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Volume 7 Issue 4
Dec.  2016
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Article Navigation >  Journal of Tropical Biology  > 2016  >  7(4): 466-471

HUANG Shanlingzi, LI Guoping. Effects of Curcumin on Blood Glucose of Diabetic Rats[J]. Journal of Tropical Biology, 2016, 7(4): 466-471. doi: 10.15886/j.cnki.rdswxb.2016.04.010
Citation: HUANG Shanlingzi, LI Guoping. Effects of Curcumin on Blood Glucose of Diabetic Rats[J]. Journal of Tropical Biology, 2016, 7(4): 466-471. doi: 10.15886/j.cnki.rdswxb.2016.04.010
shu

Effects of Curcumin on Blood Glucose of Diabetic Rats

doi: 10.15886/j.cnki.rdswxb.2016.04.010

  • 1. College of Ocean, Hainan University, Haikou, Hainan 570228, China;

  • 2. Hainan People's Hospital, Haikou, Hainan 570311, China

  • Received Date: 2016-11-16
  • The diabetic rats were induced by streptozotocin（ STZ） at a dose of 65 mg·kg-1. The rats were randomly divided into normal group,diabetic group and curcumin treatment group（ n = 10）. The rats of each group were treated for 8 weeks. The results showed that curcumin treatment significantly lowered the blood glucose level and increased the expression of hepatic glycogen and the phosphorylation of Akt in the diabetic rats as compared with the diabetic group. Moreover,HE staining results also showed that the curcumin treatment group had a reduced liver injury when compared with the diabetic group. These results suggest that curcumin has an obvious role in regulating the disturbance of glucose metabolism in diabetic rats. This function of curcumin is associated with its role in upregulating the activity of Akt signaling pathway,and improving the antioxidative activity and reducing hepatic injury.
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Effects of Curcumin on Blood Glucose of Diabetic Rats

doi: 10.15886/j.cnki.rdswxb.2016.04.010
  • 1. College of Ocean, Hainan University, Haikou, Hainan 570228, China;
  • 2. Hainan People's Hospital, Haikou, Hainan 570311, China
  • Received Date: 2016-11-16

Abstract: The diabetic rats were induced by streptozotocin（ STZ） at a dose of 65 mg·kg-1. The rats were randomly divided into normal group,diabetic group and curcumin treatment group（ n = 10）. The rats of each group were treated for 8 weeks. The results showed that curcumin treatment significantly lowered the blood glucose level and increased the expression of hepatic glycogen and the phosphorylation of Akt in the diabetic rats as compared with the diabetic group. Moreover,HE staining results also showed that the curcumin treatment group had a reduced liver injury when compared with the diabetic group. These results suggest that curcumin has an obvious role in regulating the disturbance of glucose metabolism in diabetic rats. This function of curcumin is associated with its role in upregulating the activity of Akt signaling pathway,and improving the antioxidative activity and reducing hepatic injury.

HUANG Shanlingzi, LI Guoping. Effects of Curcumin on Blood Glucose of Diabetic Rats[J]. Journal of Tropical Biology, 2016, 7(4): 466-471. doi: 10.15886/j.cnki.rdswxb.2016.04.010
Citation: HUANG Shanlingzi, LI Guoping. Effects of Curcumin on Blood Glucose of Diabetic Rats[J]. Journal of Tropical Biology, 2016, 7(4): 466-471. doi: 10.15886/j.cnki.rdswxb.2016.04.010
shu

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