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Volume 10 Issue 2
Jun.  2019
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Article Navigation >  Journal of Tropical Biology  > 2019  >  10(2): 208-214

ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
Citation: ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
shu

Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy

doi: 10.15886/j.cnki.rdswxb.2019.02.018

  • 1. Institute of Biophysics School of Life Sciences, Lanzhou University, Lanzhou Gansu, 730000 China;

  • 2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou, Hainan 571101 China

  • Received Date: 2019-05-08
  • Rev Recd Date: 2019-05-30
  • Hydrogen sulfide（H2S） is an endogenous gas signaling molecule, often synergistic with carbon monoxide and nitric oxide, and plays an important role in the regulation of angiogenesis, neural activity, glucose metabolism, antioxidant and inflammatory reactions. However, endogenous H2S metabolic abnormalities are associated with many diseases, including cancer, hypertension, diabetes, and neurodegenerative diseases. Therefore, the regulation of endogenous H2S is of great significance for the treatment of the H2S related diseases and clinical studies. In the present study, the main research method is to evaluate the effect of endogenous H2S in human pathology, supplemented with exogenous H2S so as to seek breakthroughs in pathology and find therapeutic targets of H2S and its products in diseases by relying on this research method. In this paper, we will focus on the recent progress of H2S donor and H2S in inflammation and autophagy, two of the most popular pathology-related studies, and the potential research methods of endogenous H2S quantifying.The research prospect and development direction of H2S are prospected.
  • [1] SAJID A, AAMIR N, SHAGHEF E, et al.Effects of hydrogen sulfide on postharvest physiology of fruits and vegetables:An overview[J].Scientia Horticulturae, 2019, 243:290-299.
    [2] YANG Q, LI D H.Progress and protective effect of H2S on the pathogenesis of diabetic retinopathy[J].International Journal of Ophthalmology, 2014 (1):67-70.
    [3] YANG C T, CHEN L, XU S, et al.Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders[J].Frontiers in Pharmacology, 2017 (8):664.
    [4] YU Q, WANG B R, ZHAO T Z, et al.NaHS Protects against the Impairments Induced by Oxygen-Glucose Deprivation in Different Ages of Primary Hippocampal Neurons[J].Frontiers in Cellular Neuroscience, 2017, 11.DOI: 10.3389/fncel.2017.00067.
    [5] LIN J, CHEN M, LIU D, et al.Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose induced injury by inhibiting the necroptosis pathway[J].International Journal of Molecular Medicine, 2017, 41 (3):1477-1486.
    [6] ZHEN Y L, WU Q M, DING Y Q, et al.Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway[J].Oncology Letters, 2018, 15 (5):6562-6570.
    [7] ZHOU J, LU X H, FAN J J, et al.GYY4137 Promotes Mice Feeding Behavior via Arcuate Nucleus Sulfur-Sulfhydrylation and AMPK Activation[J].Frontiers in Pharmacolog, 2018 (9).DOI: 10.3389/fphar.2018.00966.
    [8] FALLER S, HAUSLER F, GOEFT A, et al.Hydrogen sulfde limits neutrophil transmigration, infammation, and oxidative burst in lipopolysaccharide-induced acute lung injury[J].Scientific Reports, 2018, 8 (1):14676.
    [9] LAZAREVIC M, MAZZON E, MOMCILOVIC M, et al.The H2S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide[J].Molecules, 2018, 23.DOI: 10.3390/molecules23112966.
    [10] DRAPAL A, KOSZELEWSKI D, TOMASOVAL, et al.Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats[J].Acta Biochimica Polonica., 2017, 64 (3):561-566.
    [11] YANG C T, ZHENG Z H, WANG R Y, et al.A novel pH-controlled hydrogen sulfide donor protects gastric mucosa from aspirin-induced injury[J].Journal of Molecular Cell Biology, 2017, 21 (10):2441-2451.
    [12] JURKOWSKA H, WROBEL M, SZLEZAK D, et al.New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor[J].Amino Acids, 2018, 50 (6):699-709.
    [13] WU W, HOU C L, MU X P, et al.H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing[J].Oxidative Medicine and Cellular Longevity, 2017.DOI: 10.1155/2017/5707830.
    [14] ZHANG D, WANG X L, TIAN X Y, et al.The increased endogenous sulfur Dioxide acts as a compensatory Mechanism for the Downregulated endogenous hydrogen sulfide Pathway in the endothelial cell inflammation[J].Frontiersin Immunology, 2018 (9).DOI: 10.3389/fimmu.2018.00882.
    [15] JIN H F, DU J B.“Waste gas is not waste”:advance in the research of hydrogen sulfide[J].Acta Physiologica Sinica, 2010, 62 (6):495-504.
    [16] PERRY M M, TILDY B, PAPI A, et al.The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide[J].Respiratory Research, 2018, 19.DOI: 10.1186/s12931-018-0788-x.
    [17] FALLER S, SEILER R, DONUS R, et al.Correction:Pre-and posttreatment with hydrogen sulfide prevents ventilator-induced lung injury by limiting inflammation and oxidation[J].Plos One, 2017, 12 (10).DOI: 10.1371/journal.pone.0186532.
    [18] ZHAO H L, PAN P Y, YANG Y, et al.Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats[J].Journal of Neuroinflammation, 2017, 14.DOI: 10.1186/s12974-017-0940-4.
    [19] ASKARI H, SEIFI B, KADKHODAEE M, et al.Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis[J].Excli Journal, 2018, 17:14-23.
    [20] MAGIEROWSKI M, MAGIEROWSKA K, SURMIAK M, et al.The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation[J].Journal of Physiology and Pharmacology, 2017, 68 (5):749-756.
    [21] ZHANG G Y, WANG D Y, LU D, et al.Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways[J].Oxidative Medicine and Cellular Longevity, 2018 (5):15.
    [22] CHEN Y H, JIN S, TENG X, et al.Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress[J].Oxidative Medicine and Cellular Longevity, 2018.DOI: 10.1155/2018/6717212.
    [23] LIU Y, LIAO R B, QIANG Z R, et al.Pro-inflammatory cytokine-driven PI3K/Akt/Sp1 signalling and H2S production facilitates the pathogenesis of severe acute pancreatitis[J].Bioscience Reports, 2017, 37 (2).DOI: 10.1042/BSR20160483.
    [24] WU J C, SUN Y, LIU N, et al.Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy[J].Cell Death and Disease, 2017, (8).DOI: 10.1038/cddis.2017.380.
    [25] LI L, XIAO T, LI F, et al.Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats[J].Molecular Medicine Reports, 2017, 16 (2):1715-1722.
    [26] JI L, LI L, QU F Z, et al.Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway[J].Journal of Cellular and Molecular Medicine, 2016, 20 (12):2349-2361.
    [27] SUN L, ZHANG S, YU C Y, et al.Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway[J].American Journal of physiology-endocrinology andmetabolism, 2015, 309 (11):925-935.
    [28] WANG S S, CHEN Y H, DING H G, et al.Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway[J].Cell Death and Disease, 2017, (8).DOI: 10.1038/cddis.2017.18.
    [29] CHENG P, WANG F, CHEN K, et al.Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways[J].Mediators of Inflammation, 2014.DOI: 10.1155/2014/935251.
    [30] LI L, JIANG H K, LI Y P, et al.Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury[J].Journal of Biomedical Science, 2015, 22:50-60.
    [31] XIE L, YU SF, YANG K, et al.Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury[J/OL].Oxidative Medicine and Cellular Longevity, 2017.https://doi.org/10.1155/2017/8640284.
    [32] ZHANG M Y, SHAN H Y, CHANG P, et al.Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice[J].Plos One, 2014, 9 (1):87241.
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Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy

doi: 10.15886/j.cnki.rdswxb.2019.02.018
  • 1. Institute of Biophysics School of Life Sciences, Lanzhou University, Lanzhou Gansu, 730000 China;
  • 2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou, Hainan 571101 China
  • Received Date: 2019-05-08
  • Rev Recd Date: 2019-05-30

Abstract: Hydrogen sulfide（H2S） is an endogenous gas signaling molecule, often synergistic with carbon monoxide and nitric oxide, and plays an important role in the regulation of angiogenesis, neural activity, glucose metabolism, antioxidant and inflammatory reactions. However, endogenous H2S metabolic abnormalities are associated with many diseases, including cancer, hypertension, diabetes, and neurodegenerative diseases. Therefore, the regulation of endogenous H2S is of great significance for the treatment of the H2S related diseases and clinical studies. In the present study, the main research method is to evaluate the effect of endogenous H2S in human pathology, supplemented with exogenous H2S so as to seek breakthroughs in pathology and find therapeutic targets of H2S and its products in diseases by relying on this research method. In this paper, we will focus on the recent progress of H2S donor and H2S in inflammation and autophagy, two of the most popular pathology-related studies, and the potential research methods of endogenous H2S quantifying.The research prospect and development direction of H2S are prospected.

ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
Citation: ZHOU Li, LIN Chang-jun, ZHOU Peng. Research Progress on the Role and Mechanism of Hydrogen Sulfide in Inflammation and Autophagy[J]. Journal of Tropical Biology, 2019, 10(2): 208-214. doi: 10.15886/j.cnki.rdswxb.2019.02.018
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