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Volume 8 Issue 1
Mar.  2017
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Article Navigation >  Journal of Tropical Biology  > 2017  >  8(1): 58-63

GUO Fengjuan, MEI Wenli, SHAO Hang, DONG Wenhua, LI Wei, GAI Cuijuan, LI Shaopeng, DAI Haofu. Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia[J]. Journal of Tropical Biology, 2017, 8(1): 58-63. doi: 10.15886/j.cnki.rdswxb.2017.01.010
Citation: GUO Fengjuan, MEI Wenli, SHAO Hang, DONG Wenhua, LI Wei, GAI Cuijuan, LI Shaopeng, DAI Haofu. Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia[J]. Journal of Tropical Biology, 2017, 8(1): 58-63. doi: 10.15886/j.cnki.rdswxb.2017.01.010
shu

Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia

doi: 10.15886/j.cnki.rdswxb.2017.01.010

  • 1. Hainan University, College of Horticulture and Landscape Architecture, Haikou, Hainan 570228;

  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;

  • 3. Hainan Engineering Research Center of Agarwood, Haikou, Hainan 571101, China

  • Received Date: 2016-09-23
  • Rev Recd Date: 2016-10-13
  • Nine derivatives of 2-（ 2-phenylethyl） chromone were isolated from the agarwood originating from Gyrinops salicifolia by the column chromatography method with ODS,silica gel,Sephadex LH-20,etc,and their structures were then identified by using wave spectroscopy. The compounds were identified by using colorimetry as 6-hydroxy-2-（ 2-phenylethyl） chromone（ 1）,6-hydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 2）,6,8-dihydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 3）,6-methoxy-2-[2-（ 3-methoxy-4-hydroxyphenyl） ethyl] chromone（ 4）,（ 5R,6R,7S,8R）-5,6,7,8-tetrahydro-5,6,7,8-hydroxy-2-（ 2-phenylethyl）-4-hydrogen-chromone（ 5）,5α,6β,7β,8α-trihydroxy-methoxy-2-（ 2-phenylethyl）-4 hydrogen-chromone（ 6）,6-hydroxy-7-methoxy2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 7）,（ 5S,6S,7S,8R）-2-[2-（ 4-methoxyphenyl） ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone（ 8） and 8-chloro-6-hydroxy-2-（ 2-phenylethyl）chromen-4-one（ 9）. All of the compounds were isolated from agarwood originating from Gyrinops salicifolia for the first time. All the chemical constituents above were tested for acetylcholinesterase inhibitory activity using the Ellman method. The result indicated that compounds 2,4,8,9 exhibited inhibitory activities against acetylcholinesterase.
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Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia

doi: 10.15886/j.cnki.rdswxb.2017.01.010
  • 1. Hainan University, College of Horticulture and Landscape Architecture, Haikou, Hainan 570228;
  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;
  • 3. Hainan Engineering Research Center of Agarwood, Haikou, Hainan 571101, China
  • Received Date: 2016-09-23
  • Rev Recd Date: 2016-10-13

Abstract: Nine derivatives of 2-（ 2-phenylethyl） chromone were isolated from the agarwood originating from Gyrinops salicifolia by the column chromatography method with ODS,silica gel,Sephadex LH-20,etc,and their structures were then identified by using wave spectroscopy. The compounds were identified by using colorimetry as 6-hydroxy-2-（ 2-phenylethyl） chromone（ 1）,6-hydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 2）,6,8-dihydroxy-2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 3）,6-methoxy-2-[2-（ 3-methoxy-4-hydroxyphenyl） ethyl] chromone（ 4）,（ 5R,6R,7S,8R）-5,6,7,8-tetrahydro-5,6,7,8-hydroxy-2-（ 2-phenylethyl）-4-hydrogen-chromone（ 5）,5α,6β,7β,8α-trihydroxy-methoxy-2-（ 2-phenylethyl）-4 hydrogen-chromone（ 6）,6-hydroxy-7-methoxy2-[2-（ 4-methoxyphenoxy） ethyl]chromone（ 7）,（ 5S,6S,7S,8R）-2-[2-（ 4-methoxyphenyl） ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone（ 8） and 8-chloro-6-hydroxy-2-（ 2-phenylethyl）chromen-4-one（ 9）. All of the compounds were isolated from agarwood originating from Gyrinops salicifolia for the first time. All the chemical constituents above were tested for acetylcholinesterase inhibitory activity using the Ellman method. The result indicated that compounds 2,4,8,9 exhibited inhibitory activities against acetylcholinesterase.

GUO Fengjuan, MEI Wenli, SHAO Hang, DONG Wenhua, LI Wei, GAI Cuijuan, LI Shaopeng, DAI Haofu. Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia[J]. Journal of Tropical Biology, 2017, 8(1): 58-63. doi: 10.15886/j.cnki.rdswxb.2017.01.010
Citation: GUO Fengjuan, MEI Wenli, SHAO Hang, DONG Wenhua, LI Wei, GAI Cuijuan, LI Shaopeng, DAI Haofu. Active Acetylcholinesterase Inhibitory Components in Gyrinops salicifolia[J]. Journal of Tropical Biology, 2017, 8(1): 58-63. doi: 10.15886/j.cnki.rdswxb.2017.01.010
shu

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