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Volume 7 Issue 4
Dec.  2016
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Article Navigation >  Journal of Tropical Biology  > 2016  >  7(4): 517-521

JIN Yan, LI Yiying, DONG Lin, WU Younan, ZHANG Xiaopo. Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome[J]. Journal of Tropical Biology, 2016, 7(4): 517-521. doi: 10.15886/j.cnki.rdswxb.2016.04.018
Citation: JIN Yan, LI Yiying, DONG Lin, WU Younan, ZHANG Xiaopo. Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome[J]. Journal of Tropical Biology, 2016, 7(4): 517-521. doi: 10.15886/j.cnki.rdswxb.2016.04.018
shu

Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome

doi: 10.15886/j.cnki.rdswxb.2016.04.018

  • 1. School of Pharmaceutical Science, Hainan Medical University, Haikou, Hainan 571199;

  • 2. School of Basic Medical Science, Hainan Medical University, Haikou, Hainan 571199

  • Received Date: 2016-08-05
  • NLRP3,belonging to one of the inflammasomes,can be activated by pathogens of various diseases or danger signals and hence plays an important role in the onset and development of various diseases including diabetes. Inhibition of NLRP3 inflammasome expression has since turned to be a hot topic for medicinal research in the world. The inhibiting substances of the NLRP3 inflammasome can be found via either synthetic or natural method. The research progress in natural inhibition of the NLRP3 inflammasome were reviewed from some databases such as CNKI,Pubmed,etc. More than 20 compounds were found to inhibit the NLRP2 inflammasome,of which flavonoids,terpenoids,and alkaloids were described. This review might provide scientific evidence for developing new drugs in the future.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome

doi: 10.15886/j.cnki.rdswxb.2016.04.018
  • 1. School of Pharmaceutical Science, Hainan Medical University, Haikou, Hainan 571199;
  • 2. School of Basic Medical Science, Hainan Medical University, Haikou, Hainan 571199
  • Received Date: 2016-08-05

Abstract: NLRP3,belonging to one of the inflammasomes,can be activated by pathogens of various diseases or danger signals and hence plays an important role in the onset and development of various diseases including diabetes. Inhibition of NLRP3 inflammasome expression has since turned to be a hot topic for medicinal research in the world. The inhibiting substances of the NLRP3 inflammasome can be found via either synthetic or natural method. The research progress in natural inhibition of the NLRP3 inflammasome were reviewed from some databases such as CNKI,Pubmed,etc. More than 20 compounds were found to inhibit the NLRP2 inflammasome,of which flavonoids,terpenoids,and alkaloids were described. This review might provide scientific evidence for developing new drugs in the future.

JIN Yan, LI Yiying, DONG Lin, WU Younan, ZHANG Xiaopo. Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome[J]. Journal of Tropical Biology, 2016, 7(4): 517-521. doi: 10.15886/j.cnki.rdswxb.2016.04.018
Citation: JIN Yan, LI Yiying, DONG Lin, WU Younan, ZHANG Xiaopo. Recent Advance in Natural Product Inhibitors of NLRP3 Inflammosome[J]. Journal of Tropical Biology, 2016, 7(4): 517-521. doi: 10.15886/j.cnki.rdswxb.2016.04.018
shu

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