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Volume 5 Issue 1
Mar.  2014
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Article Navigation >  Journal of Tropical Biology  > 2014  >  5(1): 78-83

ZHAI Hongli, WANG Hui, ZHANG Xiuli, CAI Caihong, MEI Wenli, DAI Haofu. Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells[J]. Journal of Tropical Biology, 2014, 5(1): 78-83. doi: 10.15886/j.cnki.rdswxb.2014.01.006
Citation: ZHAI Hongli, WANG Hui, ZHANG Xiuli, CAI Caihong, MEI Wenli, DAI Haofu. Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells[J]. Journal of Tropical Biology, 2014, 5(1): 78-83. doi: 10.15886/j.cnki.rdswxb.2014.01.006
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Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells

doi: 10.15886/j.cnki.rdswxb.2014.01.006

  • 1. College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China;

  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops/Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;

  • 3. School of Pharmaceutical Science, Medical College of Binzhou, Shandong 264003, China

  • Received Date: 2014-03-06
  • Model of cell injury induced by H2O2 was set up to evaluate the protective effect of the extracts derived from Alpinia officinarum Hance on PC12 cells injured by H2O2. Cell survival rate was detected by the MTT method,and the cell morphology was observed under fluorescence microscope. The leakage rate of lactate dehydrogenase（ LDH）,malonaldehyde（ MDA） content,activities of superoxide dismutase（ SOD） and glutathione peroxidase（ GSH-Px） in PC12 cells were analyzed when PC12 cells were treated with the extracts from A. officinarum. The extracts obviously decreased the LDH leakage rate and the MDA content,but increased activities of SOD and GSH-Px in PC12 cells in a dose-dependent manner. It is thus inferred that the extracts of A. officinarum have an obviously protective effect on PC12 cells injured by H2O2. A neuroprotective medicine might be derived from these extracts which need further study.
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Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells

doi: 10.15886/j.cnki.rdswxb.2014.01.006
  • 1. College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China;
  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops/Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;
  • 3. School of Pharmaceutical Science, Medical College of Binzhou, Shandong 264003, China
  • Received Date: 2014-03-06

Abstract: Model of cell injury induced by H2O2 was set up to evaluate the protective effect of the extracts derived from Alpinia officinarum Hance on PC12 cells injured by H2O2. Cell survival rate was detected by the MTT method,and the cell morphology was observed under fluorescence microscope. The leakage rate of lactate dehydrogenase（ LDH）,malonaldehyde（ MDA） content,activities of superoxide dismutase（ SOD） and glutathione peroxidase（ GSH-Px） in PC12 cells were analyzed when PC12 cells were treated with the extracts from A. officinarum. The extracts obviously decreased the LDH leakage rate and the MDA content,but increased activities of SOD and GSH-Px in PC12 cells in a dose-dependent manner. It is thus inferred that the extracts of A. officinarum have an obviously protective effect on PC12 cells injured by H2O2. A neuroprotective medicine might be derived from these extracts which need further study.

ZHAI Hongli, WANG Hui, ZHANG Xiuli, CAI Caihong, MEI Wenli, DAI Haofu. Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells[J]. Journal of Tropical Biology, 2014, 5(1): 78-83. doi: 10.15886/j.cnki.rdswxb.2014.01.006
Citation: ZHAI Hongli, WANG Hui, ZHANG Xiuli, CAI Caihong, MEI Wenli, DAI Haofu. Neuroprotective Effect of Extracts from Alpinia Officinarum Hance on PC12 Cells[J]. Journal of Tropical Biology, 2014, 5(1): 78-83. doi: 10.15886/j.cnki.rdswxb.2014.01.006
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