Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of <i>Epinephelus akaara</i>

LI An; MA Jianzhong; REN Peng; SHAO Xinbing

doi:10.15886/j.cnki.rdswxb.20240097

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Volume 16 Issue 1

Mar. 2025

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Article Navigation > Journal of Tropical Biology > 2025 > 16(1): 152-162

LI An, MA Jianzhong, REN Peng, SHAO Xinbing. Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara[J]. Journal of Tropical Biology, 2025, 16(1): 152-162. doi: 10.15886/j.cnki.rdswxb.20240097

Citation:

LI An, MA Jianzhong, REN Peng, SHAO Xinbing. Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara[J]. Journal of Tropical Biology, 2025, 16(1): 152-162. doi: 10.15886/j.cnki.rdswxb.20240097

Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

doi: 10.15886/j.cnki.rdswxb.20240097

Zhejiang Mariculture Research Institute/Zhejiang Key Laboratory of Exploitation and Preservation of Coast Bio-resource/Wenzhou Key Laboratory of Marine Genetics and Breeding, Wenzhou, Zhejiang 325005, China

Received Date: 2024-06-11
Rev Recd Date: 2024-07-15
Publish Date: 2025-03-15

Abstract

An attempt was made to investigate the effects of quercetin（QE） added in the diet on the growth performance, serum and liver antioxidant capacity, and intestinal microflora of Epinephelus akaara. The QE was added to the basal feed at the respective concentrations of 0（FM）, 0.60（QE1）, 0.12（QE2）, 0.18（QE3） and 0.24（QE4） mmol · kg^-1, and used to feed E. akaara with its initial weight（150 ± 5.17） g for 56 days. The growth performance, and the antioxidant enzyme activities of serum and liver were measured, and the intestinal flora structure were analyzed by using high-throughput sequencing. The results showed that the growth rate（WGR）tended to increase and then decrease with the increase of QE in the diet, but was significantly higher than that of the control group（P ＜ 0.05）, and was the highest in the QE2 group. Compared with the FM group,supplementation of QE in the feed significantly increased the activities of serum glutathione peroxidase（GPX）activity（P ＜ 0.05） and reduced the content of malondialdehyde（MDA）（P ＜ 0.05）. An appropriate addition of QE significantly increased the activities of liver enzymes such as SOD, CAT, and GPX（P ＜ 0.05）, and reduced the content of MDA in the liver（P ＜ 0.05）. Compared with the FM group, the number of operational taxonomic units（OTUs） in each QE addition group showed an upward trend, and increased significantly in the QE3 and QE4groups（P ＜ 0.05）. Alpha diversity showed that compared to the control group, the QE3 and QE4 groups showed a significantly upward trend in the ACE, Chao1, Shannon index, and a significantly downward trend in the Simpson index（P ＜ 0.05）. Beta diversity analysis showed significant differences between the QE3 and QE4 groups and the FM group（P ＜ 0.05）. Compared with the FM group, the relative abundance of Fusobacteriota in each group with QE addition was significantly reduced（P ＜ 0.05）; the relative abundance of genera Staphylococcus and Desulfovibrio decreased significantly（P ＜ 0.05）, while the relative abundance of genus Turicibacter increased significantly（P ＜ 0.05）. In summary, adding of QE at a rate of 1.2-2.4 mmol·kg^-1 to the diet can improve the growth performance and antioxidant enzyme activity of E. akaara, and enhance its intestinal microbial diversity and intestinal microbiota composition.
- Epinephelus akaara,
- quercetin,
- growth performance,
- antioxidant,
- intestinal microflora

References

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Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

Zhejiang Mariculture Research Institute/Zhejiang Key Laboratory of Exploitation and Preservation of Coast Bio-resource/Wenzhou Key Laboratory of Marine Genetics and Breeding, Wenzhou, Zhejiang 325005, China

Received Date: 2024-06-11

Rev Recd Date: 2024-07-15

Publish Date: 2025-03-15

Key words:

Abstract: An attempt was made to investigate the effects of quercetin（QE） added in the diet on the growth performance, serum and liver antioxidant capacity, and intestinal microflora of Epinephelus akaara. The QE was added to the basal feed at the respective concentrations of 0（FM）, 0.60（QE1）, 0.12（QE2）, 0.18（QE3） and 0.24（QE4） mmol · kg^-1, and used to feed E. akaara with its initial weight（150 ± 5.17） g for 56 days. The growth performance, and the antioxidant enzyme activities of serum and liver were measured, and the intestinal flora structure were analyzed by using high-throughput sequencing. The results showed that the growth rate（WGR）tended to increase and then decrease with the increase of QE in the diet, but was significantly higher than that of the control group（P ＜ 0.05）, and was the highest in the QE2 group. Compared with the FM group,supplementation of QE in the feed significantly increased the activities of serum glutathione peroxidase（GPX）activity（P ＜ 0.05） and reduced the content of malondialdehyde（MDA）（P ＜ 0.05）. An appropriate addition of QE significantly increased the activities of liver enzymes such as SOD, CAT, and GPX（P ＜ 0.05）, and reduced the content of MDA in the liver（P ＜ 0.05）. Compared with the FM group, the number of operational taxonomic units（OTUs） in each QE addition group showed an upward trend, and increased significantly in the QE3 and QE4groups（P ＜ 0.05）. Alpha diversity showed that compared to the control group, the QE3 and QE4 groups showed a significantly upward trend in the ACE, Chao1, Shannon index, and a significantly downward trend in the Simpson index（P ＜ 0.05）. Beta diversity analysis showed significant differences between the QE3 and QE4 groups and the FM group（P ＜ 0.05）. Compared with the FM group, the relative abundance of Fusobacteriota in each group with QE addition was significantly reduced（P ＜ 0.05）; the relative abundance of genera Staphylococcus and Desulfovibrio decreased significantly（P ＜ 0.05）, while the relative abundance of genus Turicibacter increased significantly（P ＜ 0.05）. In summary, adding of QE at a rate of 1.2-2.4 mmol·kg^-1 to the diet can improve the growth performance and antioxidant enzyme activity of E. akaara, and enhance its intestinal microbial diversity and intestinal microbiota composition.

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Reference (52)

[1]	刘泓宇,李立贤, STEPHEN A,等.酵母培养物对珍珠龙胆石斑鱼生长性能、肠道形态、免疫功能和抗病力的影响[J]. 广东海洋大学学报, 2021, 41(3):1-11.
[2]	梅华迪,田琦,屈圣富,等.槲皮素的生理功能及其在鸡生产上的应用[J]. 中国畜牧兽医, 2022, 49(6):2116-2128.
[3]	袁天翔.槲皮素对奶牛免疫功能、生产性能的影响[J]. 饲料研究, 2022, 45(15):18-22.
[4]	姚佳颖,毛彦军,王杉杉,等.槲皮素对猪肠上皮细胞利用蛋白质的作用机制[J]. 动物营养学报, 2021, 33(1):553-562.
[5]	谭子涵,王帅杰,胡玉妍,等.槲皮素干预猪流行性腹泻病毒感染幼龄仔猪回肠蛋白质组的研究[J]. 饲料研究,2022, 45(15):36-41.
[6]	LI M, ZHU X, TIAN J, et al. Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish(Channa argus) [J]. Aquaculture, 2019, 501:473-481.
[7]	PORRAS D, NISTAL E, MARTÍNEZ-FLÓREZ S, et al.Protective effect of quercetin on high-fat diet-induced nonalcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gutliver axis activation[J]. Free Radical Biology&Medicine,2017, 102:188-202.
[8]	DOÑATE C, BALASCH J C, CALLOL A, et al. The effects of immunostimulation through dietary manipulation in the rainbow trout; evaluation of mucosal immunity[J]. Marine Biotechnology, 2010, 12(1):88-99.
[9]	JIA E, YAN Y, ZHOU M, et al. Combined effects of dietary quercetin and resveratrol on growth performance,antioxidant capability and innate immunity of blunt snout bream(Megalobrama amblycephala) [J]. Animal Feed Science and Technology, 2019, 256:114268.
[10]	XU Z, LI X, YANG H, et al. Dietary quercetin improved the growth, antioxidation, and flesh quality of grass carp(Ctenopharyngodon idella) [J]. Journal of the World Aquaculture Society, 2019, 50(6):1182-1195.
[11]	AWAD E, AUSTIN D, LYNDON A R. Effect of black cumin seed oil(Nigella sativa) and nettle extract(Quercetin) on enhancement of immunity in rainbow trout,Oncorhynchus mykiss(Walbaum) [J]. Aquaculture, 2013,388/389/390/391:193-197.
[12]	AWAD E, AWAAD A S, ANGELES ESTEBAN M.Effects of dihydroquercetin obtained from deodar(Cedrus deodara) on immune status of gilthead seabream(Sparus aurata L.) [J]. Fish&Shellfish Immunology, 2015, 43(1):43-50.
[13]	SHIN H S, YOO J H, MIN T S, et al. Effect of quercetin on the activity and mRNA expression of antioxidant enzymes and physiological responses in olive flounder(Paralichthys olivaceus) exposed to cadmium[J]. AsianAustralasian Journal of Animal Sciences, 2010, 23(6):742-749.
[14]	ZHANG Y, XIAO C, ZHU F. Effects of dietary quercetin on the innate immune response and resistance to white spot syndrome virus in Procambarusclarkii[J]. Fish&Shellfish Immunology, 2021, 118:205-212.
[15]	DA SILVA PÊS T, SACCOL E M H, JEREZ-CEPA I, et al. Quercetin attenuates endocrine and metabolic responses to oxytetracycline in silver catfish(Rhamdia quelen) [J]. Comparative Biochemistry and Physiology Toxicology&Pharmacology:CBP, 2020, 238:108864.
[16]	WANG J, JIANG Y, LI X, et al. Dietary protein requirement of juvenile red spotted grouper(Epinephelus akaara) [J]. Aquaculture, 2016, 450:289-294.
[17]	JIANG Y D, WANG J T, HAN T, et al. Effect of dietary lipid level on growth performance, feed utilization and body composition by juvenile red spotted grouper(Epinephelus akaara) [J]. Aquaculture International, 2015,23(1):99-110.
[18]	罗君,付伟杰,杨二军,等.槲皮素对杂交石斑鱼生长性能,抗氧化能力和肠道菌群的影响[J]. 广东海洋大学学报, 2022,42(4):13-22.
[19]	夏莹莹,邹田德,李硕,等.槲皮素的营养生理功能及其饲用化前景[J]. 动物营养学报, 2021, 33(2):729-736.
[20]	王婷,陈景龙,靳杰豪,等.槲皮素对高脂饲料饲养青鱼生长性能、抗氧化能力、脂代谢和肠道菌群的影响[J]. 动物营养学报, 2023, 35(10):6598-6613.
[21]	孙如意,程银峰,张博洋,等.饲料中添加槲皮素对黄河鲤生长性能,消化酶活性以及免疫和抗氧化功能的影响[J]. 动物营养学报, 2023, 35(4):2514-2523.
[22]	DONG Y Z, XIA T, LIN J B, et al. Quercetin attenuates high-fat diet-induced excessive fat deposition of spotted seabass(Lateolabrax maculatus) through the regulatory for mitochondria and endoplasmic reticulum[J]. Frontiers in Marine Science, 2021, 8:746-811.
[23]	RADOVANOVIC J, BANJAC K, OBRADOVIC M, et al.Antioxidant enzymes and vascular diseases[J]. Exploration of Medicine, 2021:544-555.
[24]	WANG Y, NIU S, LI B, et al. Improvement of stability and in vivo antioxidant effect of human glutathione peroxidase mutant by PEGylation[J]. International Journal of Pharmaceutics, 2021, 609:121-152.
[25]	HASHIM Z, ILYAS A, ZARINA S. Therapeutic effect of hydrogen peroxide via altered expression of glutathione Stransferase and peroxiredoxin-2 in hepatocellular carcinoma[J]. Hepatobiliary&Pancreatic Diseases International:HBPD INT, 2020, 19(3):258-265.
[26]	ZHENG L, XIE S, ZHUANG Z, et al. Effects of yeast and yeast extract on growth performance, antioxidant ability and intestinal microbiota of juvenile Pacific white shrimp(Litopenaeus vannamei) [J]. Aquaculture, 2021, 530:735-941.
[27]	ALUANI D, TZANKOVA V, KONDEVA-BURDINA M,et al. Evaluation of biocompatibility and antioxidant efficiency of chitosan-alginate nanoparticles loaded with quercetin[J]. International Journal of Biological Macromolecules, 2017, 103:771-782.
[28]	XU D, HU M J, WANG Y Q, et al. Antioxidant activities of quercetin and its complexes for medicinal application[J]. Molecules, 2019, 24(6):11-23.
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Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

doi: 10.15886/j.cnki.rdswxb.20240097

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Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

doi: 10.15886/j.cnki.rdswxb.20240097

Zhejiang Mariculture Research Institute/Zhejiang Key Laboratory of Exploitation and Preservation of Coast Bio-resource/Wenzhou Key Laboratory of Marine Genetics and Breeding, Wenzhou, Zhejiang 325005, China

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Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

doi: 10.15886/j.cnki.rdswxb.20240097

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通讯作者: 陈斌, bchen63@163.com

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Effects of quercetin on growth performance, antioxidant capacity and intestinal microflora of Epinephelus akaara

doi: 10.15886/j.cnki.rdswxb.20240097

Zhejiang Mariculture Research Institute/Zhejiang Key Laboratory of Exploitation and Preservation of Coast Bio-resource/Wenzhou Key Laboratory of Marine Genetics and Breeding, Wenzhou, Zhejiang 325005, China

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