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Volume 8 Issue 3
Sep.  2017
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Article Navigation >  Journal of Tropical Biology  > 2017  >  8(3): 248-254

ZHANG Yu, KONG Fandong, MA Qingyun, XIE Qingyi, HUANG Shengzhuo, ZHOU Liman, DAI Haofu, DENG Shiming, ZHAO Youxing. Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03[J]. Journal of Tropical Biology, 2017, 8(3): 248-254. doi: 10.15886/j.cnki.rdswxb.2017.03.002
Citation: ZHANG Yu, KONG Fandong, MA Qingyun, XIE Qingyi, HUANG Shengzhuo, ZHOU Liman, DAI Haofu, DENG Shiming, ZHAO Youxing. Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03[J]. Journal of Tropical Biology, 2017, 8(3): 248-254. doi: 10.15886/j.cnki.rdswxb.2017.03.002
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Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03

doi: 10.15886/j.cnki.rdswxb.2017.03.002

  • 1. Ministry of Education Key Laboratory of Tropical Biological Resources/College of Ocean, Hainan University, Haikou, Hainan 570228, China;

  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 570228, China

  • Received Date: 2017-03-30
  • Rev Recd Date: 2017-04-20
  • A strain SCS-KFD03 of Aspergillus sp.was isolated from Sipunculus nudus collected from Haikou Bay,and fermented.Active constituents were isolated and purified from the fermentation broth and hyphae of the strain SCS-KFD03 by using various chromatographic techniques,including Silica gel,Sephadex LH-20 column and HPLC chromatography.Seven compounds（1-7） were extracted from the secondary metabolites of the strain SCS-KFD03 and identified as 3β,5α-dihydroxy-（22 E,24 R）-ergosta-7,22-dien-6-one（1）,3β,4α-dihydroxy-26-methoxyer gosta-7,24（28）-dien-6-one（2）,（22 E,24 R）-ergosta-5,7,22-trien-3β-ol（3）,leporin B（4）,astellolide G（5）,astellolide B（6） and astellolide A（7）.The bio-activity evaluation of these compounds showed that compounds 2,3,5 and 6 had a certain antioxidant activity towards DPPH free radical.The compound 2 also exhibited a weak inhibitory activity against acetyl cholinesterase,and the compound 4 had a higher inhibitory activity against α-glucosidase than the positive control acarbose.
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Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03

doi: 10.15886/j.cnki.rdswxb.2017.03.002
  • 1. Ministry of Education Key Laboratory of Tropical Biological Resources/College of Ocean, Hainan University, Haikou, Hainan 570228, China;
  • 2. Ministry of Agriculture Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 570228, China
  • Received Date: 2017-03-30
  • Rev Recd Date: 2017-04-20

Abstract: A strain SCS-KFD03 of Aspergillus sp.was isolated from Sipunculus nudus collected from Haikou Bay,and fermented.Active constituents were isolated and purified from the fermentation broth and hyphae of the strain SCS-KFD03 by using various chromatographic techniques,including Silica gel,Sephadex LH-20 column and HPLC chromatography.Seven compounds（1-7） were extracted from the secondary metabolites of the strain SCS-KFD03 and identified as 3β,5α-dihydroxy-（22 E,24 R）-ergosta-7,22-dien-6-one（1）,3β,4α-dihydroxy-26-methoxyer gosta-7,24（28）-dien-6-one（2）,（22 E,24 R）-ergosta-5,7,22-trien-3β-ol（3）,leporin B（4）,astellolide G（5）,astellolide B（6） and astellolide A（7）.The bio-activity evaluation of these compounds showed that compounds 2,3,5 and 6 had a certain antioxidant activity towards DPPH free radical.The compound 2 also exhibited a weak inhibitory activity against acetyl cholinesterase,and the compound 4 had a higher inhibitory activity against α-glucosidase than the positive control acarbose.

ZHANG Yu, KONG Fandong, MA Qingyun, XIE Qingyi, HUANG Shengzhuo, ZHOU Liman, DAI Haofu, DENG Shiming, ZHAO Youxing. Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03[J]. Journal of Tropical Biology, 2017, 8(3): 248-254. doi: 10.15886/j.cnki.rdswxb.2017.03.002
Citation: ZHANG Yu, KONG Fandong, MA Qingyun, XIE Qingyi, HUANG Shengzhuo, ZHOU Liman, DAI Haofu, DENG Shiming, ZHAO Youxing. Analysis of Chemical Constituents from the Marine-derived Fungus Aspergillus sp. SCS-KFD03[J]. Journal of Tropical Biology, 2017, 8(3): 248-254. doi: 10.15886/j.cnki.rdswxb.2017.03.002
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