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Volume 6 Issue 4
Dec.  2015
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Article Navigation >  Journal of Tropical Biology  > 2015  >  6(4): 474-477

LI Xiaodan, HU Yuanyan, YU Shurun, DING Qing, LUO Sulan, ZHANGSUN Dongting. Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model[J]. Journal of Tropical Biology, 2015, 6(4): 474-477. doi: 10.15886/j.cnki.rdswxb.2015.04.018
Citation: LI Xiaodan, HU Yuanyan, YU Shurun, DING Qing, LUO Sulan, ZHANGSUN Dongting. Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model[J]. Journal of Tropical Biology, 2015, 6(4): 474-477. doi: 10.15886/j.cnki.rdswxb.2015.04.018
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Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model

doi: 10.15886/j.cnki.rdswxb.2015.04.018

  • Key Laboratory of Tropical Biological Resources, Ministry of Education; Haikou Key Lab for Marine Drugs Hainan University, Haikou, Hainan 570228, China

  • Received Date: 2015-04-14
  • Eligible Sprague Dawley（ SD） male rats were chosen to make chronic constriction injury（ CCI） model of the rat sciatic nerve,and CCI mechanical pain thresholds in different positions of the hind paw of rats were measured and compared to determine the best position for measurement. No significant difference was found in pain threshold among Positions 1,2 and 3 before CCI surgery（ P ＞0. 05）,whereas highly significant difference were observed between the Positions 1 or 2 and Position 3 after surgery of hind paw（ P ＜0. 001） and no significant difference was between Positions 1 and 2（ P ＞0. 05）. For the hind paw prior to surgery no significant difference was observed in pain threshold between the Positions 1 or 3 and the Position 2 in the hind paw,but significant difference were found between the Positions 1 and 2（ P ＜0. 05）. The Position 2 is the best place for measurement of mechanical pain threshold in CCI rats.
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Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model

doi: 10.15886/j.cnki.rdswxb.2015.04.018
  • Key Laboratory of Tropical Biological Resources, Ministry of Education; Haikou Key Lab for Marine Drugs Hainan University, Haikou, Hainan 570228, China
  • Received Date: 2015-04-14

Abstract: Eligible Sprague Dawley（ SD） male rats were chosen to make chronic constriction injury（ CCI） model of the rat sciatic nerve,and CCI mechanical pain thresholds in different positions of the hind paw of rats were measured and compared to determine the best position for measurement. No significant difference was found in pain threshold among Positions 1,2 and 3 before CCI surgery（ P ＞0. 05）,whereas highly significant difference were observed between the Positions 1 or 2 and Position 3 after surgery of hind paw（ P ＜0. 001） and no significant difference was between Positions 1 and 2（ P ＞0. 05）. For the hind paw prior to surgery no significant difference was observed in pain threshold between the Positions 1 or 3 and the Position 2 in the hind paw,but significant difference were found between the Positions 1 and 2（ P ＜0. 05）. The Position 2 is the best place for measurement of mechanical pain threshold in CCI rats.

LI Xiaodan, HU Yuanyan, YU Shurun, DING Qing, LUO Sulan, ZHANGSUN Dongting. Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model[J]. Journal of Tropical Biology, 2015, 6(4): 474-477. doi: 10.15886/j.cnki.rdswxb.2015.04.018
Citation: LI Xiaodan, HU Yuanyan, YU Shurun, DING Qing, LUO Sulan, ZHANGSUN Dongting. Comparison of Mechanical Pain Thresholds of Different Positions of Hind Paw in the Rat CCI Model[J]. Journal of Tropical Biology, 2015, 6(4): 474-477. doi: 10.15886/j.cnki.rdswxb.2015.04.018
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