[1] Fernández-Bravo A, Figueras M J. An update on the genus Aeromonas: taxonomy, epidemiology, and pathogenicity [J]. Microorganisms, 2020, 8(1): 129. https://doi.org/10.3390/microorganisms8010129 doi:  10.3390/microorganisms8010129
[2] Chen P L, Lamy B, Ko W C. Aeromonas dhakensis, an increasingly recognized human pathogen [J]. Frontiers in Microbiology, 2016, 7: 793. https://doi.org/10.3389/fmicb.2016.00793 doi:  10.3389/fmicb.2016.00793
[3] Chen P L, Wu C J, Chen C S, et al. A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent [J]. Clinical Microbiology and Infection, 2014, 20(7): O428−O434. https://doi.org/10.1111/1469-0691.12456 doi:  10.1111/1469-0691.12456
[4] 韩语, 王昕, 潘纪汶, 等. 鳄鱼源气单胞菌的毒力基因与耐药特性分析[J]. 热带生物学报, 2021, 12(1): 96−102. https://doi.org/10.15886/j.cnki.rdswxb.2021.01.014 doi:  10.15886/j.cnki.rdswxb.2021.01.014
[5] 潘纪汶, 王昕, 杨诺, 等. 牛蛙源达卡气单胞菌的分离鉴定及毒力特性分析[J]. 畜牧与兽医, 2021, 53(3): 77−83.
[6]

Lau T T V, Puah S M, Tan J A M A, et al. Flagellar motility mediates biofilm formation in Aeromonas dhakensis [J]. Microbial Pathogenesis, 2023, 177: 106059. https://doi.org/10.1016/j.micpath.2023.106059 doi:  10.1016/j.micpath.2023.106059
[7]

Li X S, Wang M Q, Di Z H, et al. Comparative assessment of ΔarnA and ΔugdΔarnA mutants of Aeromonas dhakensis as live attenuated vaccine candidates: implications for polymyxin resistance and virulence attenuation [J]. Microbial Pathogenesis, 2026, 213: 108331. https://doi.org/10.1016/j.micpath.2026.108331 doi:  10.1016/j.micpath.2026.108331
[8]

Correa N E, Lauriano C M, McGee R, et al. Phosphorylation of the flagellar regulatory protein FlrC is necessary for Vibrio cholerae motility and enhanced colonization [J]. Molecular Microbiology, 2000, 35(4): 743−755. https://doi.org/10.1046/j.1365-2958.2000.01745.x doi:  10.1046/j.1365-2958.2000.01745.x
[9]

Luo G, Huang L X, Su Y Q, et al. flrA, flrB and flrC regulate adhesion by controlling the expression of critical virulence genes in Vibrio alginolyticus [J]. Emerging Microbes & Infections, 2016, 5(1): e85. https://doi.org/10.1038/emi.2016.82 doi:  10.1038/emi.2016.82
[10] 王祖成, 马香, 李宏, 等. 维氏气单胞菌flrB基因敲除株构建及其生物特性鉴定[J]. 热带生物学报, 2021, 12(2): 161−166. https://doi.org/10.15886/j.cnki.rdswxb.2021.02.004 doi:  10.15886/j.cnki.rdswxb.2021.02.004
[11]

Chen Y W, Yeh W H, Tang H J, et al. UvrY is required for the full virulence of Aeromonas dhakensis [J]. Virulence, 2020, 11(1): 502−520. https://doi.org/10.1080/21505594.2020.1768339 doi:  10.1080/21505594.2020.1768339
[12]

Chen L Q, Wang Y, Fan L X, et al. Response regulator KdpE contributes to Aeromonas dhakensis virulence [J]. Aquaculture, 2023, 568: 739298. https://doi.org/10.1016/j.aquaculture.2023.739298 doi:  10.1016/j.aquaculture.2023.739298
[13]

Wang X Q, Yang C L, Liu H, et al. Deletion of wecA attenuates Aeromonas dhakensis and elicits protection in a zebrafish model: implications for transboundary aquaculture biosecurity [J]. Fish & Shellfish Immunology, 2026, 169: 111045. https://doi.org/10.1016/j.fsi.2025.111045 doi:  10.1016/j.fsi.2025.111045
[14] 马倩倩, 周洋, 张永安. 嗜水气单胞菌双组分系统FlrBC的功能探究[J]. 华中农业大学学报, 2022, 41(3): 221−228. https://doi.org/10.13300/j.cnki.hnlkxb.2022.03.025 doi:  10.13300/j.cnki.hnlkxb.2022.03.025
[15]

Feng W, Li X S, Yang N, et al. The PhoBR two-component system upregulates virulence in Aeromonas dhakensis C4-1 [J]. Aquaculture, 2025, 595: 741665. https://doi.org/10.1016/j.aquaculture.2024.741665 doi:  10.1016/j.aquaculture.2024.741665
[16] 王红, 赵泽林, 杨金金, 等. lsrB基因对维氏气单胞菌TH0426菌株运动性影响的研究[J]. 黑龙江畜牧兽医, 2022(11): 77−83. https://doi.org/10.13881/j.cnki.hljxmsy.2021.11.0198 doi:  10.13881/j.cnki.hljxmsy.2021.11.0198
[17]

Feng W, Huang S, Yi A D, et al. The quadruple gene mutant (aerA-ahh1-rtxA-th) of Aeromonas dhakensis shows reduced virulence and promising vaccine development potential [J]. Fish & Shellfish Immunology, 2026, 168: 110952. https://doi.org/10.1016/j.fsi.2025.110952 doi:  10.1016/j.fsi.2025.110952
[18]

Shao L T, Dong Y, Chen S S, et al. Revealing extracellular protein profile and excavating spoilage-related proteases of Aeromonas salmonicida based on multi-omics investigation [J]. International Journal of Biological Macromolecules, 2024, 265: 130916. https://doi.org/10.1016/j.ijbiomac.2024.130916 doi:  10.1016/j.ijbiomac.2024.130916
[19]

Canals R, Ramirez S, Vilches S, et al. Polar flagellum biogenesis in Aeromonas hydrophila [J]. Journal of Bacteriology, 2006, 188(2): 542−555. https://doi.org/10.1128/JB.188.2.542-555.2006 doi:  10.1128/JB.188.2.542-555.2006
[20]

Wang Z C, Tang Y Q, Li H, et al. ArgR regulates motility and virulence through positive control of flagellar genes and inhibition of diguanylate cyclase expression in Aeromonas veronii [J]. Communications Biology, 2024, 7(1): 1720. https://doi.org/10.1038/s42003-024-07392-y doi:  10.1038/s42003-024-07392-y
[21]

Gao T, Shi M M, Gao H C. Partially reciprocal replacement of FlrA and FlrC in regulation of Shewanella oneidensis flagellar biosynthesis [J]. Journal of Bacteriology, 2018, 200(7): e00796−17. https://doi.org/10.1128/JB.00796-17 doi:  10.1128/JB.00796-17
[22]

Srivastava D, Hsieh M L, Khataokar A, et al. Cyclic di-GMP inhibits Vibrio cholerae motility by repressing induction of transcription and inducing extracellular polysaccharide production [J]. Molecular Microbiology, 2013, 90(6): 1262−1276. https://doi.org/10.1111/mmi.12432 doi:  10.1111/mmi.12432
[23]

Chakraborty S, Biswas M, Dey S, et al. The heptameric structure of the flagellar regulatory protein FlrC is indispensable for ATPase activity and disassembled by cyclic-di-GMP [J]. Journal of Biological Chemistry, 2020, 295(50): 16960−16974. https://doi.org/10.1074/jbc.RA120.014083 doi:  10.1074/jbc.RA120.014083
[24]

Zhou T, Huang J H, Liu Z Q, et al. Molecular mechanisms underlying the regulation of biofilm formation and swimming motility by FleS/FleR in Pseudomonas aeruginosa [J]. Frontiers in Microbiology, 2021, 12: 707711. https://doi.org/10.3389/fmicb.2021.707711 doi:  10.3389/fmicb.2021.707711