[1] RICCI N J A B. The behaviour of ciliated protozoa [J]. Animal Behaviour, 1990, 40(6): 1048 − 1069. doi:  10.1016/S0003-3472(05)80172-1
[2] PÁRDUCZ B. Ciliary movement and coordination in ciliates [J]. International Review of Cytology, 1967, 21: 91 − 128. doi:  10.1016/S0074-7696(08)60812-8
[3] ADL S M, LEANDER B S, SIMPSON A G, et al. Diversity, nomenclature, and taxonomy of protists [J]. Systematic Biology, 2007, 56(4): 684 − 689. doi:  10.1080/10635150701494127
[4] FENG J M, JIANG C Q, WARREN A, et al. Phylogenomic analyses reveal subclass <italic>Scuticociliatia</italic> as the sister group of subclass <italic>Hymenostomatia</italic> within class <italic>Oligohymenophorea</italic> [J]. Molecular Phylogenetics and Evolution, 2015, 90: 104 − 111. doi:  10.1016/j.ympev.2015.05.007
[5] CLAMP J C, BRADBURY P C, STRUEDER-KYPKE M, et al. Phylogenetic position of the apostome ciliates (Phylum Ciliophora, Subclass Apostomatia) tested using small subunit rRNA gene sequences [J]. Denisia, 2008, 23: 395 − 402.
[6] GUTIéRREZ J C, MARTíN-GONZáLEZ A, DíAZ S, et al. Ciliates as a potential source of cellular and molecular biomarkers/biosensors for heavy metal pollution [J]. European Journal of Protistology, 2003, 39(4): 461 − 467. doi:  10.1078/0932-4739-00021
[7] GOMIERO A, DAGNINO A, NASCI C, et al. The use of protozoa in ecotoxicology: application of multiple endpoint tests of the ciliate <italic>E. crassus</italic> for the evaluation of sediment quality in coastal marine ecosystems [J]. Science of the Total Environment, 2013, 442: 534 − 544. doi:  10.1016/j.scitotenv.2012.10.023
[8] ZHOU H, LI G, HUANG R, et al. Initial study on acute toxicity of two typical Persistent Organic Pollutants(POPs) against <italic>Paramecium caudatum</italic> [J]. Asian Journal of Ecotoxicology, 2011, 6(1): 37 − 42.
[9] EISEN J A, COYNE R S, WU M, et al. Macronuclear genome sequence of the ciliate <italic>Tetrahymena thermophila</italic>, a model eukaryote [J]. Plos Biology, 2006, 4(9): 286. doi:  10.1371/journal.pbio.0040286
[10] DILLER W F J J O M. Binary fission and endomixis in the <italic>Trichodina</italic> from tadpoles (<italic>Protozoa</italic>, <italic>Ciliata</italic>) [J]. Journal of Morphology, 1928, 46(2): 521 − 561. doi:  10.1002/jmor.1050460206
[11] SIEGEL R J E C R. Nuclear differentiation and transitional cellular phenotypes in the life cycle of <italic>Paramecium</italic> [J]. Experimental Cell Research, 1961, 24(1): 6 − 20. doi:  10.1016/0014-4827(61)90242-7
[12] BERGER J D J E C R. Autogamy in <italic>Paramecium</italic> cell cycle stage-specific commitment to meiosis [J]. Experimental Cell Research, 1986, 166(2): 475 − 485. doi:  10.1016/0014-4827(86)90492-1
[13] TOVAR J. Mitosomes of parasitic protozoa: biology and evolutionary significance[M]. Berlin, Heidelberg: Springer, 2007: 277 − 300.
[14] CORLISS J O. The ciliated protozoa: characterization, classification and guide to the literature[M]. Amsterdam: Elsevier, 2016:189 − 206.
[15] BELKIN S J C O I M. Microbial whole-cell sensing systems of environmental pollutants [J]. Current opinion in microbiology, 2003, 6(3): 206 − 212. doi:  10.1016/S1369-5274(03)00059-6
[16] DURUIBE J O, OGWUEGBU M O C, EGWURUGWU J N. Heavy metal pollution and human biotoxic effects [J]. International Journal of Physical Sciences, 2007, 2(5): 112 − 118.
[17] JÄRUP L J B M B. Hazards of heavy metal contamination [J]. British medical bulletin, 2003, 68(1): 167 − 182. doi:  10.1093/bmb/ldg032
[18] TCHOUNWOU P B, YEDJOU C G, PATLOLLA A K, et al. Molecular, clinical and environmental toxicology [M]. New York and London: Springer, 2012:133 − 164.
[19] MADONI P J E P. The acute toxicity of nickel to freshwater ciliates [J]. Environmental Pollution, 2000, 109(1): 53 − 59. doi:  10.1016/S0269-7491(99)00226-2
[20] MADONI P, DAVOLI D, GORBI G J B O E C, et al. Acute toxicity of lead, chromium, and other heavy metals to ciliates from activated sludge plants [J]. Bulletin of Environmental Contamination and Toxicology, 1994, 53(3): 420 − 425.
[21] WANG S, SHI X J M. Biochemistry, molecular mechanisms of metal toxicity and carcinogenesis [J]. Molecular and Cellular Biochemistry, 2001, 222(1/2): 3 − 9. doi:  10.1023/A:1017918013293
[22] BEYERSMANN D, HARTWIG A J A O T. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms [J]. Archives of Toxicology, 2008, 82(8): 493 − 512. doi:  10.1007/s00204-008-0313-y
[23] YEDJOU C G, TCHOUNWOU P B. Oxidative stress in human leukemia (HL-60), human liver carcinoma (HepG2), and human (Jurkat-T) cells exposed to arsenic trioxide [J]. Metal Ions in Biology and Medicine, 2006, 9: 298 − 303.
[24] REHMAN A, SHAKOORI F R, SHAKOORI A R J B T. Shakoori, Heavy metal resistant freshwater ciliate, <italic>Euplotes mutabilis</italic>, isolated from industrial effluents has potential to decontaminate wastewater of toxic metals [J]. Bioresource Technology, 2008, 99(9): 3890 − 3895. doi:  10.1016/j.biortech.2007.08.007
[25] EBBS S, LASAT M, BRADY D, et al. Phytoextraction of cadmium and zinc from a contaminated soil [J]. Journal of Environmental Quality, 1997, 26(5): 1424 − 1430.
[26] IWATA H, TANABE S, SAKAI N, et al. Distribution of persistent organochlorines in the oceanic air and surface seawater and the role of ocean on their global transport and fate [J]. Environmental Science &Technology, 1993, 27(6): 1080 − 1098.
[27] ROUABHI R, BERREBBAH H, DJEBAR M J A J O B. Toxicity evaluation of flucycloxuron and diflubenzuron on the cellular model, <italic>Paramecium sp</italic>. [J]. African Journal of Biotechnology, 2006, 5(1): 45 − 48.
[28] JEONG C B, KANG H M, LEE Y H, et al. Nanoplastic ingestion enhances toxicity of persistent organic pollutants (POPs) in the monogonont rotifer Brachionus koreanus via multixenobiotic resistance (MXR)disruption [J]. Environmental Science &Technology, 2018, 52(19): 11411 − 11418.
[29] MREMA E J, RUBINO F M, BRAMBILLA G, et al. Persistent organochlorinated pesticides and mechanisms of their toxicity [J]. Toxicology, 2013, 307: 74 − 88. doi:  10.1016/j.tox.2012.11.015
[30] SWEDENBORG E, RüEGG J, MäKELä S, et al. Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders [J]. Journal of Molecular Endocrinology, 2009, 43(1): 1 − 10. doi:  10.1677/JME-08-0132
[31] KAHRU A, DUBOURGUIER H-C, BLINOVA I, et al. Biotests and biosensors for ecotoxicology of metal oxide nanoparticles: a minireview [J]. Sensors, 2008, 8(8): 5153 − 5170. doi:  10.3390/s8085153
[32] FENT K. Nanoparticles in the water cycle[M]. Berlin, Heidelberg: Springer, 2010:183 − 205.
[33] OBERDöRSTER E, ZHU S, BLICKLEY T M, et al. Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms [J]. Carbon, 2006, 44(6): 1112 − 1120. doi:  10.1016/j.carbon.2005.11.008
[34] HOEGH-GULDBERG O, HUGHES L, MCINTYRE S, et al. Assisted colonization and rapid climate change [J]. Science, 2008, 32: 1345 − 346.
[35] PRESCOTT D M J M M B R. The DNA of ciliated protozoa [J]. Microbiology and Molecular Biology Reviews, 1994, 58(2): 233 − 267.
[36] PRITCHARD A, SEILHAMER J, MAHALINGAM R, et al. Nucleotide sequence of the mitochondrial genome of <italic>Paramecium</italic> [J]. Nucleic Acids Research, 1990, 18(1): 173 − 180. doi:  10.1093/nar/18.1.173
[37] STEELE C J, BARKOCY-GALLAGHER G A, PREER L B, et al. Developmentally excised sequences in micronuclear DNA of <italic>Paramecium</italic> [J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91(6): 2255 − 2259. doi:  10.1073/pnas.91.6.2255
[38] ARNAIZ O, GOûT J-F, BéTERMIER M, et al. Gene expression in a paleopolyploid: a transcriptome resource for the ciliate <italic>Paramecium tetraurelia</italic> [J]. BMC Genomics, 2010, 11(1): 547. doi:  10.1186/1471-2164-11-547
[39] XIONG J, LU X, ZHOU Z, et al. Transcriptome analysis of the model protozoan, <italic>Tetrahymena thermophila</italic>, using deep RNA sequencing [J]. PloS one, 2012, 7(2): 30630. doi:  10.1371/journal.pone.0030630
[40] CHEAIB M, DEHGHANI AMIRABAD A, NORDSTRöM K J, et al. Epigenetic regulation of serotype expression antagonizes transcriptome dynamics in <italic>Paramecium tetraurelia</italic> [J]. DNA Research, 2015, 22(4): 293 − 305. doi:  10.1093/dnares/dsv014
[41] ISHAQ S L, WRIGHT A-D G J A E M. Design and validation of four new primers for next-generation sequencing to target the 18S rRNA genes of gastrointestinal ciliate protozoa [J]. Applied and Environmental Microbiology, 2014, 80(17): 5515 − 5521. doi:  10.1128/AEM.01644-14
[42] CAVALIER-SMITH T, LEE J J J T J O P. Protozoa as hosts for endosymbioses and the conversion of symbionts into organelles [J]. The Journal of Protozoology, 1985, 32(3): 376 − 379. doi:  10.1111/j.1550-7408.1985.tb04031.x